Extracorporeal Blood Oxygenation and Ozonation, often called EBOO, is a procedure in which blood is drawn from a vein, passed through a filter while it is exposed to oxygen and ozone, and then returned to the body. It is promoted in some wellness settings for a long list of chronic conditions. Patients in Beverly Hills and Los Angeles who are researching EBOO often arrive with real symptoms and real frustration, and they deserve a clear, respectful explanation of what the evidence shows, what it does not show, and how the procedure is regulated.
Before founding My Concierge MD, Dr. David Nazarian worked as an attending physician in the emergency department at the UCLA-VA Hospital and as a hospitalist at Huntington Memorial Hospital and Arcadia Methodist Hospital. That acute care background shapes how he evaluates any procedure that takes blood outside the body, with safety, equipment, and emergency readiness as the first questions rather than the last. He is a diplomate of the American Board of Internal Medicine and completed his internal medicine residency at Huntington Memorial Hospital, a USC teaching affiliate.
“When a procedure takes blood outside the body, the questions about safety, equipment, and monitoring come first. Only after those are answered does it make sense to talk about potential benefits.” — Dr. Nazarian
What EBOO Is and How It Is Regulated
EBOO is related to other forms of ozone therapy, such as ozonated autohemotherapy, but it circulates a larger volume of blood through an external circuit. It is not the same as dialysis, which filters blood for patients with kidney failure, or extracorporeal membrane oxygenation (ECMO), which supports critically ill patients in the hospital. Those are established treatments for specific conditions, and their success does not transfer to EBOO.EBOO should not be presented as an established treatment for cancer, Lyme disease, autoimmune disorders, arthritis, or chronic fatigue. Patients with these conditions need appropriate diagnosis and evidence-based care, which should not be delayed or replaced by an unproven intervention.
The regulatory picture is important for anyone considering this procedure:
- FDA Approval Status: EBOO is not FDA-approved for the treatment of any disease or condition.
- Federal Ozone Regulation: FDA regulations state that ozone has no known useful medical application in specific, adjunctive, or preventive therapy, which limits how ozone-generating devices may be marketed.
- Device Enforcement: In July 2025, the FDA issued a warning letter to an EBOO device manufacturer citing unapproved devices and manufacturing deficiencies.
- Published Research: Available studies are small and mostly uncontrolled, and no large randomized trials show that EBOO improves outcomes for chronic disease.
Common Concerns That Lead Patients to Ask About EBOO
Many patients who ask about EBOO are living with persistent fatigue, a diagnosis of Lyme disease, an autoimmune condition, arthritis, or ongoing symptoms after an infection. Some have heard that EBOO can “detoxify” the blood. These are understandable reasons to look for answers, and each deserves a careful response.
EBOO has not been shown to be an effective treatment for cancer, Lyme disease, autoimmune disorders, arthritis, or chronic fatigue. General claims about removing toxins also fall short of medical evidence, since a meaningful detoxification claim would need to identify the specific substance removed and show that removing it improves health. The greater risk is delay, because conditions like these often respond to established treatment and can worsen when care is postponed.
This is where an internal medicine evaluation adds real value. Dr. Nazarian can review prior testing, order appropriate laboratory blood work, look for treatable contributors such as thyroid disease, anemia, sleep disorders, and medication effects, and coordinate with specialists through our primary care and internal medicine services.
Safety Considerations for Any Blood-Handling Procedure
Because EBOO removes and returns blood through an external circuit, it carries risks that are very different from a routine IV vitamin infusion. These include infection, clotting in the circuit, bleeding in patients taking blood thinners, damage to red blood cells, fainting or low blood pressure, and injury at the vein access site. Safe performance depends on the device, sterile technique, trained staff, continuous monitoring, and a plan for emergencies. For these reasons, the availability of house calls or mobile IV services should never be taken to mean that EBOO is appropriate in a home or hotel setting.
If you have received any blood-handling procedure and develop chest pain, shortness of breath, confusion, fainting, or signs of a serious allergic reaction, call 911 or go to the nearest emergency room.
What to Expect During an EBOO Consultation
Your visit begins with a thorough review of your symptoms, diagnoses, medications, and prior treatments. Dr. Nazarian will discuss the specific procedure and device you are considering, its regulatory status, the human evidence for your condition, and the risks. He will also outline established alternatives and, when helpful, coordinate referrals so that proven care is not delayed. The goal is an informed decision, not a sales conversation.
Frequently Asked Questions About EBOO
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EBOO is a procedure that circulates blood outside the body, exposes it to oxygen and ozone through a filter, and returns it to the bloodstream. It is distinct from dialysis, ECMO, and routine IV therapy.
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No. EBOO is not FDA-approved for any condition, and the FDA has taken enforcement action involving EBOO devices. Ask any provider to identify the exact device and its regulatory status.
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There is no reliable evidence that EBOO treats these conditions. Patients should continue appropriate care and discuss established options with their treating physicians.
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Detoxification claims are not supported by evidence. A valid claim would need to identify a specific substance, show that the procedure removes it, and demonstrate a health benefit.
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Blood-handling procedures require specialized equipment, sterile conditions, trained staff, monitoring, and emergency support, so mobile availability of other services does not make EBOO suitable outside a clinical setting.
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Reported and potential risks include infection, clotting, bleeding, damage to red blood cells, low blood pressure, fainting, and vein injury. Your risk depends on your health, your medications, and the setting.
Why Choose Dr. Nazarian for an EBOO Consultation
- Coordinated Care: Referrals and follow-up are managed directly by your physician.
- Acute Care Experience: Emergency and hospital medicine training informs every safety discussion.
- Honest Evidence Review: You will hear what the research does and does not support.
- Whole-Person Evaluation: Underlying causes of chronic symptoms are investigated, not overlooked.
Talk to a Beverly Hills Internist About EBOO
If you are researching EBOO for a chronic health concern, a thoughtful medical consultation can help you weigh the evidence, understand the risks, and find the most effective path forward. Dr. Nazarian welcomes patients from Beverly Hills and across Los Angeles who want straightforward answers. Schedule a medical consultation to discuss your symptoms, current care, and questions about EBOO and established alternatives.
Regulatory reference: FDA warning letter to O3UV, LLC (July 7, 2025).
Medically reviewed by David Nazarian, MD on