Peptide therapy for weight management uses targeted amino acid sequences that influence pathways related to fat metabolism, satiety signaling, and growth hormone activity. At My Concierge MD, peptide therapy is prescribed within a broader medical weight loss program, not offered as a standalone solution.
Each protocol is overseen by Dr. David Nazarian — a board-certified internal medicine physician trained at UCLA, the Sackler School of Medicine, and Huntington Memorial Hospital, a USC-affiliated teaching institution — with selection based on clinical evaluation, metabolic profile, and current regulatory considerations. FDA-approved options are prioritized where clinically appropriate.
Initially found Dr Nazarian for medical weight loss and then found out about all the regenerative and anti aging medicine services his medical clinic offers. They have one of the best IV exosomes and exosome therapy available. They have been able to help me overcome my fatigue as welll as lose weight safely and effectively. Their semaglutide injections for weight loss has really helped me lose weight and feel so much better.
How Peptides Transform Your Weight Loss Journey
For many individuals in Beverly Hills, traditional weight loss methods often fall short for some patients. Peptide therapy is one option physicians may consider as part of a broader treatment plan. Peptides are short chains of amino acids that serve as signaling messengers in the body, involved in functions such as metabolism, hormonal regulation, and tissue repair.
At My Concierge MD, we focus on creating personalized peptide protocols designed specifically for your metabolism and lifestyle. Our medical approach is comprehensive and grounded in current clinical evidence, with the goal of supporting a weight loss journey that is safe and sustainable. Individual results vary, and no specific outcome can be guaranteed. Our clinic is recognized for excellence in concierge care, with multiple Patients’ Choice Awards underscoring our commitment to quality.
Key Peptides That Enhance Metabolic Health
Several peptides are discussed in connection with metabolic health, though their regulatory status and evidence base differ significantly:
- Semaglutide: This FDA-approved GLP-1 medication is supported by clinical trial evidence for improving insulin sensitivity and reducing appetite in eligible patients. It is typically prescribed alongside, not instead of, dietary and lifestyle changes, and individual results vary.
- CJC-1295 + Ipamorelin: Studied for their potential to stimulate growth hormone release; clinical data are limited, and FDA has identified safety concerns with CJC-1295 specifically. These are not FDA-approved for weight management.
- AOD 9604: Investigated in early research for a potential targeted effect on fat metabolism without impacting blood sugar; it is not FDA-approved for weight loss, and human clinical evidence remains limited.
Evidence for these peptides varies significantly by compound. FDA-approved options like semaglutide have a substantial clinical evidence base, while others remain investigational, and their safety and effectiveness for weight loss have not been established in humans. Dr. Nazarian can discuss which options, if any, are appropriate given your health history and goals.
The Mechanism Behind Peptide Therapy for Weight Loss
Some peptide therapies work by mimicking the body’s natural hormones involved in hunger and metabolism, with the goal of influencing appetite, energy expenditure, and fat storage. The strength of evidence varies widely by peptide. FDA-approved options like semaglutide have demonstrated efficacy in clinical trials, contributing to sustained fat loss and improved metabolic markers for many patients, while other peptides discussed for weight management have far more limited human clinical data.
Personalized Treatment Plans Tailored Just for You
At My Concierge MD, we believe that weight loss is not a cookie-cutter process. Every patient receives a custom treatment plan that considers their specific metabolic requirements and lifestyle habits.
Through direct physician oversight, we monitor progress and adjust therapies to ensure optimal outcomes, aligning with your personal health goals. With our extensive training and experience, our medical professionals provide a concierge level of care that emphasizes prevention and long-term health.
Why Beverly Hills Chooses My Concierge MD for Peptide Therapy
Our concierge medicine model emphasizes personalized, relationship-based care for patients across Beverly Hills. Led by Dr. David Nazarian, a board-certified internal medicine physician with years of experience, My Concierge MD offers comprehensive medical care tailored to your unique health profile. Patients benefit from in-office visits, house calls, and hotel visits, as well as expedited appointments, all designed for convenience and accessibility.
Maintaining Your Results with Sustainable Lifestyle Changes
While peptide therapy can significantly enhance your weight loss journey, sustainable results also rely on lifestyle changes. We provide ongoing support through personalized wellness programs focused on diet, exercise, and recovery strategies, ensuring that your transformation is not just effective but lasting.
MOTS-C and Mitochondrial-Derived Peptide Therapy
MOTS-C is a 16-amino-acid peptide encoded by the mitochondrial genome rather than the nuclear genome — making it one of a small class of mitochondrial-derived peptides under active research for metabolic regulation, insulin sensitivity, and energy homeostasis. It has drawn attention in metabolic medicine for its potential influence on weight, glucose handling, and exercise capacity.
Mechanism of Action
MOTS-C functions as an activator of AMP-activated protein kinase (AMPK) — a key cellular energy sensor that regulates glucose uptake, fatty acid oxidation, and mitochondrial function. By activating AMPK signaling, MOTS-C has been investigated for its potential effects on:
- Glucose Metabolism: Influence on insulin sensitivity and cellular glucose uptake in preclinical models.
- Mitochondrial Efficiency: Support for mitochondrial energy production and cellular metabolism.
- Body Composition: Modulation of adiposity and lean tissue ratios in animal studies.
- Exercise Response: Potential enhancement of skeletal muscle adaptation to physical activity.
Research interest in MOTS-C as a metabolic regulator has grown substantially over recent years, though large-scale human clinical trial evidence remains limited.
Current Regulatory Status
MOTS-C is not FDA-approved for any human use as of 2026. The regulatory landscape has shifted meaningfully in recent months: MOTS-C was removed from the FDA’s Category 2 restricted list effective April 22, 2026, and the Pharmacy Compounding Advisory Committee (PCAC) is scheduled to review MOTS-C – alongside several other peptides – on July 23, 2026 to consider whether it should be added to the 503A Bulks List for legal compounding pharmacy access.
Until the PCAC review concludes and the FDA acts on its recommendations, MOTS-C remains in a regulatory transition period. Patients interested in MOTS-C should also be aware that it is listed on the World Anti-Doping Agency (WADA) Prohibited List under section S4.4.1 (AMPK activators) and is banned at all times for competitive athletes.
How My Concierge MD Approaches MOTS-C
MOTS-C consultations at the practice are integrated into a broader metabolic and weight loss evaluation:
- Education and Informed Decision-Making: Each consultation includes a discussion of MOTS-C’s current regulatory status, available clinical evidence, the pending PCAC review, and athletic compliance considerations.
- Evaluation for FDA-Approved Alternatives: Most patients interested in MOTS-C are also candidates for FDA-approved metabolic and weight loss therapies – including tirzepatide and semaglutide – which are typically discussed first.
- Active Monitoring of Regulatory Developments: The practice tracks ongoing FDA and PCAC action regarding peptide compounding to provide patients with current information as decisions are made through 2026.
- Physician-Led Decision-Making: All discussions regarding peptide therapy take place within the structured clinical framework that defines the practice’s approach to weight management.
Frequently Asked Questions About Peptide Therapy
-
Peptides are short chains of amino acids that signal various biological functions in the body.
-
Peptide therapy is typically administered through injections, tailored specifically to fit your individual health needs.
-
Safety depends on the specific peptide. FDA-approved options like semaglutide have an established safety profile when supervised by a physician. Other peptides discussed for weight management are not FDA-approved and have more limited safety data; Dr. Nazarian reviews the current evidence and regulatory status for any peptide you’re considering.
-
Individual results may vary based on several factors, including adherence to therapy and associated lifestyle changes.
-
Yes, our medical team can develop an integrated approach that may combine peptide therapy with other health services tailored to your needs.
-
MOTS-C is a 16-amino-acid peptide encoded by the mitochondrial genome that activates AMPK – a cellular enzyme involved in energy regulation. Through AMPK activation, MOTS-C has been studied for its potential effects on insulin sensitivity, glucose metabolism, mitochondrial function, and body composition. Most research evidence to date comes from preclinical and small clinical studies.
-
MOTS-C is not FDA-approved for any human use as of 2026. The FDA removed MOTS-C from its Category 2 restricted compounding list in April 2026, and the Pharmacy Compounding Advisory Committee is scheduled to review whether MOTS-C should be added to the 503A Bulks List for legal compounding pharmacy access in July 2026. The regulatory status may change after that review.
-
MOTS-C and GLP-1 medications work through entirely different mechanisms. GLP-1 medications such as tirzepatide and semaglutide are FDA-approved for chronic weight management and act primarily on appetite signaling and gastric emptying. MOTS-C activates cellular energy pathways through AMPK. FDA-approved GLP-1 therapies have a much larger evidence base for weight loss in human trials and remain the first-line consideration for most patients during a medical weight loss consultation.
-
No. MOTS-C is on the World Anti-Doping Agency Prohibited List under section S4.4.1 (AMPK activators) and is banned at all times for competitive athletes governed by WADA, USADA, or sport-specific anti-doping codes. Patients who are subject to anti-doping testing – whether at the professional, collegiate, or competitive amateur level — should not pursue MOTS-C therapy.
Why Choose Us
Here’s why My Concierge MD is the preferred choice for peptide therapy in Beverly Hills:
- Board-certified and trained medical professionals overseeing every treatment.
- Personalized weight loss plans that adapt to your needs.
- Comprehensive medical care with an emphasis on preventive health.
- Convenience of house calls and same-day appointments.
- Integration of advanced regenerative and longevity medicine.
Take the First Step Towards Your Health Goals Today
If you’re ready to explore peptide therapy for weight loss and metabolic health in Beverly Hills, connect with My Concierge MD today. With Dr. David Nazarian’s extensive experience and multiple recognitions including being named a Top 10 Doctor in Los Angeles, you can embark on a transformative journey toward achieving your health objectives. Begin your path to effective and holistic weight management now!
Medically reviewed by David Nazarian, MD on